4,5-Difluoro-2-(trimethylsilyl)phenyl trifluoromethanesulfonate
4,5-difluoro-2-(trimethylsilyl)phenyl triflate
CAS: 217813-00-8
Molecular Formula: C10H11F5O3SSi
4,5-Difluoro-2-(trimethylsilyl)phenyl trifluoromethanesulfonate - Names and Identifiers
4,5-Difluoro-2-(trimethylsilyl)phenyl trifluoromethanesulfonate - Physico-chemical Properties
| Molecular Formula | C10H11F5O3SSi |
| Molar Mass | 334.34 |
| Density | 1.38±0.1 g/cm3(Predicted) |
| Boling Point | 274.9±40.0 °C(Predicted) |
4,5-Difluoro-2-(trimethylsilyl)phenyl trifluoromethanesulfonate - Introduction
4,5-difluoro-2-(trimethylsilyl)phenyl triflate is an organic compound with the chemical formula C10H11F2O3SSi. It is a white or white-like solid with a strong pungent odor.
This compound is commonly used in organic synthesis reactions as a catalyst, a protecting group or a reaction intermediate. It is widely used in the synthesis of aromatic compounds, substitution reactions and the sulfonylation of alcohols. Its high electron density and acidity make it a powerful phosphate group transfer reagent.
Preparation of 4,5-difluoro-2-(trimethylsilyl)phenyl triflate can be prepared by the reaction of trimethyl (4,5-difluorophenyl) silane and trifluoromethanesulfonic acid. The trimethyl (4,5-difluorophenyl) silane first reacts with hydrofluoric acid to generate the corresponding trimethyl (4,5-difluorosilicyl) phenylfluorosilane, and then reacts with trifluoromethanesulfonic acid to obtain the target product.
Regarding safety information, this compound is irritating and corrosive. Appropriate protective equipment should be worn during handling to avoid contact with skin, eyes and respiratory tract. If you come into contact with skin or eyes, rinse immediately with plenty of water for at least 15 minutes and seek medical attention. In addition, 4,5-difluoro-2-(trimethylsilyl)phenyl triflate should be stored in airtight containers, away from sources of ignition and oxidizing agents.
This compound is commonly used in organic synthesis reactions as a catalyst, a protecting group or a reaction intermediate. It is widely used in the synthesis of aromatic compounds, substitution reactions and the sulfonylation of alcohols. Its high electron density and acidity make it a powerful phosphate group transfer reagent.
Preparation of 4,5-difluoro-2-(trimethylsilyl)phenyl triflate can be prepared by the reaction of trimethyl (4,5-difluorophenyl) silane and trifluoromethanesulfonic acid. The trimethyl (4,5-difluorophenyl) silane first reacts with hydrofluoric acid to generate the corresponding trimethyl (4,5-difluorosilicyl) phenylfluorosilane, and then reacts with trifluoromethanesulfonic acid to obtain the target product.
Regarding safety information, this compound is irritating and corrosive. Appropriate protective equipment should be worn during handling to avoid contact with skin, eyes and respiratory tract. If you come into contact with skin or eyes, rinse immediately with plenty of water for at least 15 minutes and seek medical attention. In addition, 4,5-difluoro-2-(trimethylsilyl)phenyl triflate should be stored in airtight containers, away from sources of ignition and oxidizing agents.
Last Update：2024-04-10 22:29:15
